BIO2420 Neurophysiology

This course is designed to provide a detailed working knowledge of how neurons function at the cellular level. We will consider neurons as electrochemically based information-processing cells, in isolation and as part of simple neural circuits. The general principles of cellular neurophysiology common to all neurons will be addressed, emphasizing non-human animals. Examples from pathophysiology, neuropharmacology, and toxicology will be considered. We will also review the sensory systems of human and non-human organisms. This course will not cover human cognition, emotional regulation, or large-scale organization. Basic knowledge of cell biology (at the level of BIO 1112 or BIO 2412) is required, including the following topics: subcellular organelles, membrane structure and the fluid mosaic model, the central dogma, and protein structure.

Credits

4 sh

Prerequisite

BIO 1112 and BIO 1113, or BIO 2412 and BIO 2413

Course Types

Science

Offered

• Fall

Learning Outcomes

1. • Obtain deep knowledge of the basic electrical functioning of neurons
   • Describe the process neurons use to maintain and manipulate a voltage
   • Calculate the membrane voltage using appropriate formulas
   • Describe how neurons’ voltages change when they signal each other
   • Describe the communication process between two neurons
   • Understand the relationship between neurotransmitters and their receptors
   • Understand the relationship between signaling molecules at the synapse
   • Understand the mechanisms involved in synapse modification and plasticity
   • Understand and apply the factors that influence input integration of a neuron
   • Describe the cellular mechanisms involved in neurotransmitter release
   • Understand that human cognitive and psychological processes are based on cellular neurophysiology
   • Apply foundational cellular neurophysiology concepts to various animal species
   • Gain insight into the neurological mechanisms underlying animal behaviors
   
   Students will be expected to demonstrate learning and mastery of the material through journal article critiques/analysis and quizzes/exams.